Deepening the youth-oriented interpretation of the Party’s innovative theories in the new era is a major issue in equipping young people with Xi Jinping Thought on Socialism with Chinese Characteristics for the new era and opening up new horizons for the Party’s youth work in the new era. It represents a proactive and necessary effort by the Party to strengthen the determination of young people to unite and strive for their goals, clear up the fog of young people’s thinking, and promote the healthy growth of young people amid increasing obstacles on the journey toward national rejuvenation, a growing complexity in the ideological and public opinion landscape, and multidimensional pressures from social development. Deepening the youth-oriented interpretation of the Party’s innovative theories in the new era has the essential connotation of continuing to equip young people with the Party’s innovative theories in the new era, and “what to interpret” and “how to interpret” constitute the core direction of understanding this proposition from the content and practice point of view. From a content point of view, to explain the Party’s innovative theories in the new era, it is necessary to follow the law of thought and behavior of young people’s cognition, identification, and practice, follow the multi-dimensional target mechanism of knowledge, ability, value, and practice, and strengthen the structural design of the content of the hierarchical progression. In terms of practice, it is also necessary to grasp the intersection of “youth ‘transforming’ theory” and “theory ‘transforming’ youth”, promoting the organic synergy of interpretation object, interpretation discourse, and interpretation goal. At present, to enhance the quality and effectiveness of the youth-oriented interpretation of the Party’s innovative theories in the new era, we should adhere to the unity of “youth-oriented” and “problem-oriented”, the coordination of “hierarchical classification” and “dynamic tracking”, the combination of “innovation in thinking” and “optimization of the scene”, and the combination of “simultaneous promotion” and “long-term interaction”. Efforts will be made in the four dimensions of content production, object focus, upgrading of methods, and improvement of mechanisms, thus promoting the creative practice of improving the quality and efficiency of youth-oriented interpretation work in a holistic manner.