As an advanced form emerging from the overlap of the digital economy and industrial clusters, digital industrial clusters provide a new general-purpose technological foundation and ecosystem for industrial development and integration. Digital industrial clusters break down technical barriers between industries, foster digital innovation and entrepreneurship activities characterized by service-oriented manufacturing and centered on digital technologies and data as core resources, and bring new technological support and strong momentum for industrial integration and transformation, such as the integration of advanced manufacturing and modern services (“Two-Industry Integration”). Regarding the paths to integration, the “Two-Industry Integration” requires multi-dimensional driving forces, including market demand, technological innovation, and the digital ecosystem, while continuously cultivating emerging drivers to achieve high-frequency, in-depth interaction and synergistic development between the two industries. In terms of empowering effects, digital industrial clusters exhibit multiple enabling effects, such as factor agglomeration, technological innovation, industrial structure upgrading, and linkage and network synergy. These empowering effects of digital industrial clusters effectively correspond to the dynamic mechanism of “Two-Industry Integration”, provide the key drivers for “Two-Industry Integration” and generate new drivers, aggregate decentralized resources and services, and promote the integration and reorganization of factors like products and services. Additionally, they provide rich and efficient digital technology tools, reshape the value creation methods of the entities in both industries, optimize industrial spatial layout and structure, and create a superior digital ecosystem and development environment for the integration and mutual reinforcement of the two industries. Therefore, efforts should be accelerated to build highly competitive digital industrial clusters with significant empowering effects, cultivate and enhance the internal and external drivers for “Two-Industry Integration”, promote the innovation and diffusion of digital technologies in the cluster ecosystem, optimize the spatial layout of the two industries, and propel “Two-Industry Integration” into a new phase of deep integration.