Spatial subjectivism takes individual action as its logical starting point and emphasizes the underlying logical relationships among action, rules, and space. From the perspective of spatial subjectivism, this paper conducts in-depth reflections on the theory and practice of humanistic economics. First, the “rational man” hypothesis excludes individual action and action coordination from the theoretical framework of economics, resulting in a homogeneous view of space. In contrast, the “action man” hypothesis incorporates individual action and action coordination into the economic theory, steering economics toward a differential spatial view. Differential space is inherently linked to the development of humanistic economics. Second, the “action man” hypothesis serves as the logical starting point for contemplating the theoretical connotations of humanistic economics. Individual action and its coordination generate “spatiality” and “locality”. Once formed, these concepts profoundly influence individual perceptions and actions. The integration and exchange of different forms of “locality” create a spatial system characterized by “node-network” structures with distinct forms of “locality”. Regional openness drives the continuous evolution of “locality”, while a closed “locality” lacks vitality and constrains local socio-economic development. Finally, from the perspective of spatial subjectivism, the practice of humanistic economics must respect general rules, as respecting rules equates to respecting people. It is necessary to reshape “locality” through further reform and opening-up, exploring endogenous drivers for local development. Significant attention should be given to the logical relationships among the three types of innovation: humanistic innovation, institutional innovation, and technological innovation. Humanistic innovation should drive institutional innovation, while the latter should propel technological innovation. A new round of globalization should be advanced through “hard power”“soft power”, and “warm power”. This means that in addition to “hard power” centered on manufacturing, there must also be “soft power” in developing humanistic economics and “warm power” in respecting the cultures of other countries and regions.